TCRF
Funded Research

  • The impact of alpha catenin loss on DNA repair defects in triple negative breast cancer
    $500.000 Barry Rosenbloom, MD Senior Investigator Grant

    Triple negative breast cancer (TNBC) is an aggressive and has a high death rate, especially in black women. We have found a gene marker that may make these tumors escape chemotherapy. Our research also shows that when this marker is not present, the tumor cells respond to a very specific type of cancer therapy. Also, there might be more immune cells that come into the tumor. Therefore, we wish to expand our research help better understand the role of this marker in breast cancer growth to improve treatment of this hard to treat form of cancer.

    John Carpten, PhD
    University of Southern California
  • Targeting Monoamine Oxidase A to Expand Cancer Immune Checkpoint Blockade Therapy
    $500,000 Magnolia Council Senior Investigator Grant

    Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of many cancers; however, the existing ICB therapies can only benefit a small fraction of cancer patients, demanding an expansion of ICB therapies. Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain; small molecule MAO inhibitors (MOIs) have been developed and are clinically used for treating depression. This proposal aims to study MAO-A regulation of antitumor immunity and evaluate MAO-A blockade for cancer immunotherapy. The project has the potential to identify MAO-A as a new immune checkpoint and support repurposing MAOI antidepressants for cancer immunotherapy.

    Lili Yang, PhD
    University of California, Los Angeles

Impact begins here,
and it starts with you.

All of our research is made possible through the generous support of people like you.

Will you join us in the fight for a future free from the burden of cancer?

donate to research today

    I would like to learn more about:
    We respect your privacy, and will keep your personal information private and secure.