University of California, San Diego
$50,000 Tower Career Development Grant
Research Title:
Thrombopoietin’s stabilization of Tensin2, a protein with migrational implications
The proposed research focuses on bone marrow stem cells that mature into the diverse range of cells found in the blood: white cells, important in defense against infection; red cells, which shuttle oxygen and carbon dioxide to and from all parts of the body; and platelets, essential in blood clotting in response to injury.
Successful completion of the proposed work will advance our understanding of the intracellular events necessary for cell maturation and migration; such knowledge will aid in designing new strategies, when the normal machinery has faltered, to prevent leukemic and other cancer cell growth and metastasis.