William D. Tap, MD

University of California, Los Angeles
$25,000 Tower Career Development Grant

Research Title:
Myelodysplastic Inhibition of Protein Farnesylation: A Promising and Potentially Unifying Treatment Modality in Sarcomas

Sarcoma is a rare form of cancer that affects individuals of all ages. Its diagnosis often carries a poor prognosis, as the benefit of traditional chemotherapy has been maximized. It is critical that we discover and apply new, more efficacious therapies.

Recently, in our laboratory, we have discovered that Sarcoma cells are sensitive to a novel compound that blocks the cancer’s ability to grow and propagate. Currently, we are pursuing this compound as a treatment for patients with Sarcoma. In addition, we are using it as a scientific tool to help us unravel the molecular intricacies of this deadly disease.