Chintan Parek, MD

The Cancer Free Generation Research Grant

Research Title: Role of the Long Noncoding RNA DANCR in T Cell Acute Lymphoblastic Leukemia

Children’s Hospital of Los Angeles

Mentor: Alan Wayne, MD

T cell leukemia (T-All) is a type of blood cancer that affects children and adults. Newer treatments are urgently needed, as 20% of children and 50% of adults with T-ALL cannot be cured. Our research focuses on a recently discovered gene called DANCR, which is present at abnormally high levels in T leukemia cells. We have found that DANCR promotes the growth of leukemia cells. We are currently studying how DANCR promotes this growth of leukemia cells. These studies could ultimately lead to the development of new anti-DANCR treatments for leukemias.