Daniel Sanghoon Shin, M.D.
The Cancer Free Generation Research Grant
Research Title: Regulation of PD-L1/L2 Expression in Melanoma
Mentor: Antoni Ribas, M.D., Ph.D.
The field of immuno-oncology has evolved over the past century, however, its therapeutic application to fight cancer has just begun with recent approval of new immunotherapy drugs in 2014. Anti-PD-1 antibodies produce unprecedented long lasting responses for patients with advanced melanoma and advanced lung cancer, it is expected to be approved for many other cancer types. Dr. Shin will study the regulation of PD-L1/L2 expression in response to interferons which will be highly relevant to understanding the response and resistance from anti-PD-1/L-1 antibody therapy and its great potential to develop an assay or identify bio-markers to predict the response.