Xiaochun Yu, MD, PhD
Evanthia Roussos Torres, MD-PhD

$100,000 HOWARD AND REVA COLOVER TRUST CAREER DEVELOPMENT GRANT

Research Title: Sensitizing the tumor immune microenvironment of breast cancer

Keck School of Medicine of USC

Breast cancer is the second leading cause of cancer-related death in women. Immunotherapies
harness the body’s immune system to fight cancer, holding great promise to prevent recurrence and prolong survival. Immunotherapies have been less effective in patient’s with breast cancer in part, due to the recruitment of suppressive cells that prevent an anti-tumor effect. We will investigate strategies to decrease suppressive signals within the tumor, allowing anti-tumor signals to successfully eliminate tumor growth. We will also determine differences in suppressive signals between early versus metastatic breast cancers to improve response to immunotherapy for patients with all stages of disease.

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