Giridharan Ramsingh, MD

The Magnolia Council Research Grant

Research Title: Hematopoietic Stem Cell and Progenitor Cell Senescence and Therapy Related Acute Myeloid Leukemia

USC

Mentor: Preet Chaudhar, MD, PhD

Patients with cancer are frequently treated with chemotherapy and/or radiation therapy. A small subgroup of these patients develops a type of leukemia called Therapy-related Acute Myeloid Leukemia (tAML) as a complication. It is a deadly disease with more than 90% of the patients dying within 5 years. Based on our recent work, we think the chemotherapy exposure to normal blood stem cells causes the stem cell to undergo rapid aging and the aged stem cells turn into cancer. The proposed study is to test this idea and in the process to discover how aging of blood stem cells causes leukemia.