Guo-Min Li, PhD
$500,000 Tower Senior Investigator Grantee
Research Title: Targeting Mismatch Repair System for Cancer Therapy
University of Southern California
Despite decades of extensive studies in cancer research, cancer is still the number 2 leading cause of death in the United States. The major problem is that individual cancers display distinct genetic abnormalities, and none of the known treatments and their combination can effectively deal with these abnormalities. We have recently created a mutant DNA repair protein that irreversibly binds to cancer cell-specific DNA errors during cancer growth, leading to cell death. This application aims to develop this mutant DNA repair protein into an effective drug for cancer therapy.