Xiaochun Yu, MD, PhD
John Carpten, PhD

$500,000 SENIOR INVESTIGATOR GRANT

Research Title: The impact of alpha catenin loss on DNA repair defects in triple negative breast cancer

Keck School of Medicine of USC

Triple negative breast cancer (TNBC) is an aggressive and has a high death rate, especially in black women. We have found a gene marker that may make these tumors escape chemotherapy. Our research also shows that when this marker is not present, the tumor cells respond to a very specific type of cancer therapy. Also, there might be more immune cells that come into the tumor. Therefore, we wish to expand our research help better understand the role of this marker in breast cancer growth to improve treatment of this hard to treat form of cancer.

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