Xiaochun Yu, MD, PhD
Jun Gong, MD

$100,000 CAREER DEVELOPMENT GRANT

Research Title: Performance of hypermethylated circulating tumor DNA’s in colorectal cancer

Cedars-Sinai Medical Center

Measuring DNA produced by colorectal cancer (CRC) in blood (ctDNA) is a new method to detect return (recurrence) of CRC. We developed an in-house, blood-based ctDNA test that is less costly and easier to apply in practice. We will compare our ctDNA test’s performance to a commercial ctDNA test for detecting recurrence in patients who no longer have CRC and tumor growth or spread in patients with existing CRC. We will also analyze our test’s potential to predict recurrence in localized rectal cancer, which can be helpful to identify candidates who can be spared from unnecessary surgery (ostomy bags).

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