John Kyung Lee, M.D.
The Irving Feintech Family Foundation Research Grant
Research Title: Targeting Myc Oncoproteins in Advanved Prostate Cancer
Mentor: Owen N. Witte, M.D.
Advanced prostate cancer is a deadly disease with limited treatment options. Two members of the Myc family of cancer genes named c-Myc and N-Myc are active in the main types of lethal prostate cancer, castration-resistant prostate adenocarcinoma and small cell neuroendocrine prostate cancer. In this work, Dr. Lee will clarify the biologic functions of c-Myc and N-Myc in two unique prostate cancer models developed from normal human prostates. Dr. Lee will take advantage of these models of advanced prostate cancer to find new therapies and evaluate a promising inhibitor that directly targets the activity of N-Myc in cancer cells.