Steven Jonas, MD, PhD
$100,000 CAREER DEVELOPMENT GRANT
Research Title: Nanosystems to accelerate clinical translation and generation of cellular immunotherapies
University California Los Angeles
Some childhood cancers do not respond to chemotherapy, surgery, or radiation. For these patients, new treatments are being developed that recruit cells of the immune system to attack the cancer. To turn on these defenses, we need to deliver genetic instructions to about two hundred million immune cells, efficiently and safely. Unlike other strategies, these cells no longer need to come from the patients, who are already weakened. We have invented an engineering solution to do so and we are testing and optimizing it so that we can make this treatment widely available to patients and their doctors soon.