Xiaochun Yu, MD, PhD
$1,000,000 SENIOR INVESTIGATOR GRANT
Research Title: ADP- riboslaytion and cancer therapy
City of Hope
Chemotherapy is a key approach to treat cancer patients, especially for the patients with invasive solid tumors. To date, more than 250 anti-cancer drugs have been used for chemotherapy. However, the most commonly used anti-cancer drugs for solid tumors non-specifically abolish DNA metabolism or cell division in growing cells. Thus, long term treatment with these anti-cancer drugs will cause severe side effects and chemo-resistance. Interestingly, a set of cancers harbor mutations that cause DNA damage repair defects. In this application, we plan to use this weakness of cancer cells to target DNA damage repair pathway, and develop novel chemotherapeutic approaches.