Andre Scott Jung, MD
University of California, San Diego
2010
$
50000
Tower Career Development Grant
Thrombopoietin’s stabilization of Tensin2, a protein with migrational implications
The proposed research focuses on bone marrow stem cells that mature into the diverse range of cells found in the blood: white cells, important in defense against infection; red cells, which shuttle oxygen and carbon dioxide to and from all parts of the body; and platelets, essential in blood clotting in response to injury. Successful completion of the proposed work will advance our understanding of the intracellular events necessary for cell maturation and migration; such knowledge will aid in designing new strategies, when the normal machinery has faltered, to prevent leukemic and other cancer cell growth and metastasis.
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