Clinical Trial Network

The purpose of this research study is to understand how socioeconomic, clinical factors, resilience, and physical and psychological symptoms influence health-related quality of life among women diagnosed with metastatic breast cancer. Study activities will include completing an online anonymous survey. The survey questions are about how metastatic breast cancer and its related symptoms affect you and your quality of life. We will ask additional demographic and socioeconomic questions to help identify possible relationships.

Breast cancer treatments may have an impact on how the brain processes information and emotions as well as on a person’s attention span and behavior. To better understand and measure these changes, researchers at Memorial Sloan Kettering Cancer Center are conducting a study called Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC). The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer.

This pilot study aims to deploy a web-based study enrollment and engagement application, to enroll a minimum of 5,000 cases with breast cancer and 5,000 controls from diverse backgrounds, to obtain DNA from their saliva samples and survey questionnaires, and to perform analyses to identify genetic factors that contribute to the development of breast cancer as well as other health conditions more generally.

Although scientists have learned a great deal about a few breast cancer genes, such as BRCA1 and BRCA2, these do not fully explain the role of genetics in breast cancer—there are many more genes and mutations yet to be identified and understood. Breast cancer remains a significant health concern. This new study aims to increase our knowledge of the role of genes in causing breast cancer, potentially leading to new medications to treat, or even prevent, breast cancer.

The purpose of this study is to understand how the experience of fatigue affects physical activity participation in breast cancer survivors. This patient-centered approach will provide insight into the experience of cancer-related fatigue and how to maximize physical activity participation in this group of breast cancer survivors. This study will identify feasible and acceptable intervention strategies to implement in the future.

The project aims to improve patient-provider interactions and health outcomes among women with breast cancer. Participants in this study will be assigned to one of two groups: one that involves meetings with a trained breast cancer survivor coach or another that receives an informational booklet from the National Cancer Institute (NCI). Throughout the study, which lasts up to 36 months, participants will complete surveys at various intervals. These surveys will explore decision-making involvement and communication with healthcare providers.

This study aims to understand the effects of aerobic exercise compared with health education on memory, attention, and brain health in women with breast cancer. Study findings may help researchers design more programs that can improve memory, attention, and brain health in other women with breast cancer.