Cancer of the pancreas is the fourth leading cause of cancer-related death. Approximately 32,180 new cases are anticipated in 2005, with 31,800 expected deaths and a median overall survival of only 6 months for cancer that has spread. Our traditional chemotherapy has not been able to significantly prolong life. Cancer cells have pathways that are constitutively turned on and allow for cell growth.I plan on targeting some of these pathways and also study the mechanisms involved with uncontrolled cell growth as well as resistance. This will allow us to improve the survival and quality of life of our patients.